Metabolism of Methylmercury in Experimental Animals.

[Metabolismes of methylmercury sulfate and methylmercury iodide in animals].

Cats fed (CH3Hg)2SO4 developed the same findings as spontaneously affected cats fed the poisonous seafood from Minamata Bay. The organomercury compound in raw organs such as the liver, the kidney, and the bone marrow of the above animals did not transfer to chloroform , but it transferred easily to BAL. The methylmercury compound in organs of cats fed (CH3Hg)2SO4 and rats fed CH3HgI accumulated...

Scorpion Venom Pisoning in Experimental Animals

Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

Asbestosis in experimental animals.

Previous animal experiments with asbestos dusts have been almost entirely confined to chrysotile asbestos. It was, therefore, decided to investigate the effects of mill dusts from the three types of asbestos that are produced commercially in South Africa, namely chrysotile, amosite, and crocidolite. Chrysotile and amosite samples were relatively pure while in contrast the crocidolite dust was f...